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Objective :To explore therapeutic effect of amlodipine atorvastatin calcium tablet on hypertensive pa-tients .Methods : A total of 112 hypertensive patients treated in our hospital were randomly and equally divided into amlodipine group (received amlodipine 5mg／d) and amlodipine atorvastatin group (received amlodipine atorvastatin calcium tablet 15mg／d) ,both groups were treated for eight weeks .Therapeutic effect and incidence of adverse reac- tions ,blood pressure and blood lipids before and after treatment were compared between two groups .Results : Com-pared with before treatment ,there were significant reduction in levels of blood pressure and blood lipids (except sig-nificant rise in HDL-C level) in two groups after treatment , P＜0-05 or ＜0-01 ;compared with amlodipine group , there was significant rise in total effective rate (62-5% vs.96-4%, P＝0-001) ,and significant reduction in inci-dence rate of adverse reactions (28-5% vs.3-5%) , P＝ 0-003 ;significant reductions in levels of blood pressure [ (147-5 ± 10-1)／(90-7 ± 8-2) mmHg vs.(133-2 ± 9-4)／(86-9 ± 8-2) mmHg] ,total cholesterol [ (5-7 ± 1-3) mmol／L vs .(5-2 ± 0-8) mmol／L] ,triglyceride [(2-5 ± 1-2) mmol／L vs.(1-9 ± 0-5) mmol／L] and low density lip-oprotein cholesterol [ (4-1 ± 0-7) mmol／L vs.(3-1 ± 0-6) mmol／L] in amlodipine atorvastatin group , P＜0-05 or＜0-01- Conclusion : Amlodipine atorvastatin calcium tablet can significantly improve blood pressure and blood lipids with few adverse reactions in hypertensive patients ,which is worth extending .
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Objective:To explore safety of benapril combined amlodipine on hypertension and its influence on levels of plasm total cholesterol (TC) and triglyceride (TG).Methods:A total of 180 hypertensive patients treated in our hospital were selected,randomly and equally divided into amlodipine group and combined treatment group (received amlodipine combined benapril therapy ),both groups were continuously treated for one month.Therapeutic outcome and incidence of adverse reactions were compared between two groups.Results:After treatment,compared with amlo-dipine group,there were significant reductions in systolic blood pressure [(146.3 ± 11.9) mmHg vs.(133.4 ± 15.1) mm-Hg],diastolic blood pressure [(90.5 ± 5.9) mmHg vs.(81.4 ± 6.1) mmHg],heart rate [(85.4 ± 10.8) beats/min vs.(74.5 ± 12.6) beats/min],levels of plasm TC [(5.17 ± 1.75) mmol vs.(3.52 ± 1.85) mmol] and TG[(1.64 ± 0.14) mmol vs.(1.32 ± 0.32) mmol] in combined treatment group,P＝0.001 all.Total incidence rate of adverse reactions of combined treatment group was significantly lower than that of amlodipine group (3.3% vs.15.6%,P＝0.005).Conclu-sion:Benapril combined amlodipine can significantly reduce heart rate,blood pressure and levels of plasm total cholesterol and triglyceride in hypertensive patients.It＇s safe and effective,which is worth extending.
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<p><b>OBJECTIVE</b>To study the dynamic prevalence and epidemiological characteristics of birth defects distribution in the Tongzhou District of Beijing between 2006 and 2012.</p><p><b>METHODS</b>Data collected from the birth defects surveillance system in the Tongzhou District of Beijing between 2006 and 2012 were used. The prevalence and trends of birth defects were analyzed, also the proportion of birth defects in prenatal diagnosis was calculated.</p><p><b>RESULTS</b>Between 2006 and 2012, 1,165 cases of birth defects were identified among 92,340 births, with a prevalence of 12.62‰. The prevalence of birth defects showed an increased trend during the seven years (χ2=6.77, P<0.01). The prevalence in the flowing population (13.27‰) was higher than that in the permanent residents (11.55‰), and the former showed an upward trend during the seven years (χ2=25.02, P<0.01). The top five birth defects were congenital heart defects, polydactyly, cleft lip and/or palate, neural tube defects, and external ear malformation in turn. The prevalence of congenital heart defects and the unspecified congenital malformation increased while that of neural tube defects decreased. There was also an upward trend of the prenatal diagnosis for congenital heart defects (χ2=14.80, P<0.01).</p><p><b>CONCLUSIONS</b>The prevalence of birth defects increased in the Tongzhou District of Beijing from 2006 to 2012, and it was mainly caused by the increased prevalence of birth defects in the flowing population, the increased number of unspecified birth defects and the improvement of diagnosis technology for congenital heart defects.</p>
Subject(s)
Female , Humans , Male , China , Epidemiology , Congenital Abnormalities , Diagnosis , Epidemiology , Prenatal Diagnosis , Prevalence , Time FactorsABSTRACT
Objective To explore the effect of preventing adhesion after the orbital blowout fracture on orbit tissue by amniotic membrane. Design Experimental study. Participants Twenty-six New Zealand rabbits. Methods Establishing rabbit orbital blowout fracture model, the right orbit of twenty rabbits was repaired by hydroxyapatite (HA) parceled of amniotic membrane, and left orbit was only repaired by HA, the orbits of the other six rabbits weren't repaired. Then we got the tissue around bone after one week and one month, and compared the difference of three groups. Main Outcome Measures Inflammatory response of tissue around bone was ana- lyzed by HE, picric acid Sirius Scarlet dying, TGF-?immunohistoehemical observation. Results One week after operation, HE and im- munohistochemistry showed that the difference was not significant in inflammatory response between experimental group and control group (P=0.351, P=0.413), and difference is significant between blank group and experimental group (P=0.012, P=0.041). One month after operation, HE and immunohistoehemistry showed that the difference was significant in inflammatory response between experimental group and control group(P=0.037, P=0.048), and there is no significant difference between experimental group and blank group(P=0.285, P=0.472). Conclusion It has an important role of anti-inflammatory and anti-adhesion in the chronic stage of inflammatory after orbital blowout fracture repaired by man-made plates of amniotie membrane.